Welcome to the BMTInfonet Drug Database

This guide lists many of the drugs bone marrow, stem cell and cord blood transplants patients receive during treatment. It explains why they are used and some, but not allAcute lymphoblastic leukemia., of the possible side effects.

This guide should not be used as a substitute for a detailed discussion with your doctor and pharmacist about drugs you are being given. If you experience any side effect after taking the drug, even if they are not noted below, consult your doctor immediately.

Some of the drugs in this guide are also used outside the transplant setting. The descriptions of the drugs in this guide pertain only to their use in bone marrow, stem cell or cord blood transplantation.

If you are searching for a drug used by transplant patients and survivors that is not in this database, please contact us at drugdata@bmtinfonet.org.

This database was compiled under the direction of pharmacists knowledgeable about transplantation, but should not be construed as medical advice. Consult your doctor for information about how each drug might affect you.

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Albuterol


Trade Names: 
Proventil®
Trade Names: 
Ventolin®

Possible Uses: 
Decrease spasms in the airway as with asthma. Often used to help with breathing difficulties.

Possible Side Effects: 
Nervousness, tremor, irregular and fast heartbeat, nausea, dizziness, trouble sleeping, sweating.
Last updated on 02/01/2010

Aldesleukin


Trade Names: 
Proleukin®

Alternate Names: 
IL-2
Alternate Names: 
Interleukin-2

Possible Uses: 
An investigational drug used in BMT to boost the immune system post-transplant and aid it in eliminating any residual tumor cells.

Possible Side Effects: 
Fever, chills, flu-like symptoms, fluid retention, shortness of breath.
Last updated on 02/01/2010

Amoxicillin


Trade Names: 
Amoxil®
Trade Names: 
Polymox®
Trade Names: 
Trimox®
Trade Names: 
Wymox®

Possible Uses: 
Prevent or treat bacterial infections.

Drug Interactions: 
May decrease the effectiveness of oral contraceptives and increase the effects of anticoagulants such as warfarin or Coumadin®.

Possible Side Effects: 
Diarrhea, rash, nausea, and vomiting. If patient is allergic, may cause rash, swelling, breathing difficulties. May also cause a superinfection such as vaginal fungal infection.
Last updated on 02/01/2010

Ampicillin


Trade Names: 
Omnipen®
Trade Names: 
Polycillin®
Trade Names: 
Principen®
Trade Names: 
Totacillin®

Possible Uses: 
Prevent or treat bacterial infections.

Drug Interactions: 
May decrease the effectiveness of oral contraceptives and may increase the effects of anticoagulants such as warfarin or Coumadin®.

Possible Side Effects: 
Diarrhea, rash, nausea, vomiting. If patient has a penicillin allergy, may cause rash, swelling, breathing difficulties. May also cause a superinfection such as vaginal fungal infection.
Last updated on 02/01/2010

Calcium Acetate


Trade Names: 
PhosLo®

Possible Uses: 
Taken with meals to lower phosphorous levels in blood. If taken between meals it is used to increases calcium.

Special Notes: 
Should be taken 1-2 hours after other medications.

Drug Interactions: 
Many interactions including antibiotics and mycophenolate, check with your pharmacist.

Possible Side Effects: 
Diarrhea or constipation, vomiting, flatuence.
Last updated on 02/01/2010

Carboplatin


Trade Names: 
Paraplatin®

Alternate Names: 
CPP
Alternate Names: 
CBDCA

Possible Uses: 
A chemotherapy drug.

Special Notes: 
Derived from the metal platinum.

Possible Side Effects: 
Decreased blood counts, nausea, vomiting, diarrhea, loss of appetite, metallic taste in mouth, mouth sores, temporary hair loss, decreased potassium and magnesium in blood, numbness or tingling in hands and feet, ringing in ears, hearing damage, decreased kidney function. Rarely, allergic type reaction causing breathing difficulties with swelling of mouth and tongue.
Last updated on 02/01/2010

Chlorhexidine


Trade Names: 
Peridex®

Possible Uses: 
Prevent oral infections.

Special Notes: 
Oral rinse: completely rinse toothpaste from mouth, then swish in mouth for 30 seconds and spit out. Do not swallow.

Possible Side Effects: 
Temporary mouth and/or tongue irritation, increased tartar on teeth, metallic taste, stained tongue and/or teeth, nausea, vomiting.
Last updated on 02/01/2010

Cisplatin


Trade Names: 
Platinol®

Possible Uses: 
A chemotherapy drug.

Special Notes: 
Derived from the metal platinum. Maintaining adequate fluid intake to help prevent kidney damage, speak to your healthcare provider of how much to take in. Nausea and vomiting can be severe and can be delayed. Notify your healthcare provider if you feel signs and symptoms of infection.

Possible Side Effects: 
Decreased blood counts, nausea, vomiting, diarrhea, loss of appetite, metallic taste in mouth, mouth sores, tiredness, temporary hair loss, numbness or tingling in hands and feet, loss of potassium and magnesium in blood, ringing in ears, hearing damage, and decreased kidney function. Rarely, allergic type reactions may cause breathing difficulties with swelling of mouth and tongue.
Last updated on 02/01/2010

Epoetin Alpha


Trade Names: 
Epogen®
Trade Names: 
Procrit®

Alternate Names: 
EPO
Alternate Names: 
Erythropoietin

Possible Uses: 
Increase red blood cell counts and hemoglobin after transplant.

Special Notes: 
Medicare has put special restrictions on using this drug when anemia is based on chemotherapy.

Possible Side Effects: 
Pain at injection site, rash, chills, muscle or joint pain, headache, upset stomach, nausea, diarrhea, elevated blood pressure. Rarely, breathing difficulties, chest pain.
Last updated on 02/01/2010

Erythromycin


Trade Names: 
E-Mycin®
Trade Names: 
ERYC®
Trade Names: 
Ery-Tab®
Trade Names: 
PCE Dispertab®

Possible Uses: 
Treat or prevent infection.

Drug Interactions: 
Interferes with many drugs metabolized by the liver. May be toxic to the heart when used with astemizole or quinidine.

Possible Side Effects: 
Diarrhea, abdominal pain and cramping, nausea, vomiting, liver dysfunction, heartbeat irregularity, rash.
Last updated on 02/01/2010

Famotidine


Trade Names: 
Pepcid®

Possible Uses: 
Reduce acid in stomach, treat or prevent ulcers or reflux.

Possible Side Effects: 
Headache, dizziness, diarrhea, constipation, rash.
Last updated on 02/01/2010

Fluoxetine


Trade Names: 
Prozac®

Possible Uses: 
Treat depression or nerve-related pain.

Possible Side Effects: 
Rash, headaches, drowsiness, nausea, diarrhea, insomnia, weight loss, nervousness, dry mouth, sweating, shakiness, increased need to urinate, change in taste, fast heartbeat, breathing difficulties.
Last updated on 02/01/2010

Ibuprofen


Trade Names: 
Advil®
Trade Names: 
Haltran®
Trade Names: 
Medipren®
Trade Names: 
Motrin®
Trade Names: 
Nuprin®
Trade Names: 
Profen®
Trade Names: 
Rufen®

Possible Uses: 
Relieve minor pain and pain associated with inflammation.

Possible Side Effects: 
Nausea, vomiting, bloody urine, stool or vomit, rash, red peeling skin, swelling in face or around the eyes, reduced kidney function, poor platelet function, liver toxicity, stomach pain, dizziness, ringing in ears, swelling in feet or legs. Used only when absolutely necessary, and then with great care, due to bleeding risks.
Last updated on 02/01/2010

Imipenem


Trade Names: 
Primaxin®

Possible Uses: 
Prevent or treat bacterial infections.

Possible Side Effects: 
Rash, vein irritation, nausea, vomiting. If patient is allergic, may cause breathing difficulties, swelling of face, throat or lips, rash.
Last updated on 02/01/2010

Immune Globulin


Trade Names: 
Gamimune N®
Trade Names: 
Gammagard®
Trade Names: 
Gammar-IV®
Trade Names: 
Iveegam®
Trade Names: 
PolyGam®
Trade Names: 
Sandoglobulin®
Trade Names: 
Venoglobulin®

Alternate Names: 
IGG
Alternate Names: 
IVIG

Possible Uses: 
Prevent or treat infection while immune system is weak.

Special Notes: 
A product derived from human blood collections.

Possible Side Effects: 
Fever, chills, allergic reaction, rash, flushing, tightness in chest, dizziness, nausea, vomiting, increased blood pressure, headache, fatigue, pain in back, hip or joints, kidney damage.
Last updated on 02/01/2010

Lansoprazole


Trade Names: 
Prevacid®

Possible Uses: 
treatment or prevention of ulcers, reflux

Special Notes: 
take before eating, best before breakfast

Drug Interactions: 
possible interaction with Plavix (clopidogrel), Sprycel (dasatinib) and other medications, review with healthcare provider or pharmacist

Possible Side Effects: 
headache, constipation, diarrhea, abdominal pain
Last updated on 02/01/2010

Oxycodone with acetaminophen


Trade Names: 
Percocet®
Trade Names: 
Roxicet®
Trade Names: 
Tylox®

Possible Uses: 
Relieve mild to moderate pain.

Possible Side Effects: 
Constipation, nausea, itching, vomiting, dizziness, weakness, dry mouth, headache, blurred vision, sleepiness, rapid or slow heartbeat, breathing difficulties, swollen face, rash, hallucinations, change in behavior, confusion, tender stomach.
Last updated on 02/01/2010

Paclitaxel


Trade Names: 
Taxol®

Possible Uses: 
A chemotherapy drug. Originally developed from the pacific Yew Tree

Special Notes: 
Antihistamines(Benadryl & cimetidine) and steroids (dexamethasone) must be given before this drug to prevent hypersensitivity reactions.

Possible Side Effects: 
Nausea, vomiting, diarrhea, constipation, fever, chills, mouth sores, numbness and/or tingling in fingers and toes that may progress to hands, lower arms and feet, nerve pain, bone pain, muscle pain, tiredness, loss of appetite, temporary hair loss, heartbeat irregularities. If patient is allergic, may cause swollen face, lips or throat, breathing difficulties, lowered blood pressure. Rarely, separation of the nails from fingers. Nails re-grow when drug is discontinued.
Last updated on 02/01/2010

Palifermin


Trade Names: 
Kepivance®

Possible Uses: 
Used to prevent mucositis from radiation and/or chemotherapy. Given IV for 3 days before chemotherapy and for 3 days after chemotherapy

Possible Side Effects: 
edema, high blood pressure, fever, pain,rash, red skin, cough, runny nose. Tongue/ mouth discoloration or thickness, taste alteration.
Last updated on 02/01/2010

Penicillin


Trade Names: 
Pen Vee K®
Trade Names: 
V-Cillin®
Trade Names: 
Veetids®

Possible Uses: 
Prevent or treat bacterial infections.

Possible Side Effects: 
Skin rash, stomach upset, diarrhea, bleeding problems. If patient is allergic, may cause swollen face, throat or lips, breathing difficulties. May also cause a superinfection such as vaginal fungal infection.
Last updated on 02/01/2010

Pentamidine


Trade Names: 
Nebupent®
Trade Names: 
Pentacarinat®
Trade Names: 
Pentam®

Possible Uses: 
Can be given IV or inhalation to prevent protozoal infections.

Possible Side Effects: 
Decreased blood pressure, slow fast or irregular heartbeat, excessive hunger or thirst, nervousness, sweating, confusion, rash, itching, breathing difficulties, metallic taste, nausea, vomiting, decreased blood counts, decrease in blood sugar, change in kidney or liver function.
Last updated on 02/01/2010

Pentostatin


Trade Names: 
Nipent®

Possible Uses: 
Approved for hair cell leukemia but also used for chronic lymphocytic leukemia, T-Cell leukemia, and for acute Graft vs Host Disease

Drug Interactions: 
Echinacea

Possible Side Effects: 
Fevers, fatigue,chills, headache, rash,nausea, vomiting, diarrhea. Myleosuppression, anemia, and low platelets. Possible kidney and lung damage, as well as reactivation of previous viral infections.
Last updated on 02/01/2010

Phenytoin


Trade Names: 
Dilantin®

Possible Uses: 
Prevent or treat seizures. Also used with other pain medications to help relieve nerve pain.

Possible Side Effects: 
Sleepiness, reduced coordination, low blood pressure, involuntary eye or body movement, confusion, rash, flu-like feeling, loss of appetite, nausea, vomiting, nervousness, trouble sleeping, constipation, excess hair growth, thickening of gums. Rarely, causes severe burn like damage to skin called Stevens-Johnson syndrome. If you notice a rash that starts to get worse after being started on phenytoin, notify your doctor immediately.
Last updated on 02/01/2010

Pilocarpine


Trade Names: 
Salagen®

Possible Uses: 
Increase saliva production.

Possible Side Effects: 
Increased sweating. Occasionally, a fast heart rate.
Last updated on 02/01/2010

Piperacillin


Trade Names: 
Pipracil®

Possible Uses: 
Prevent or treat bacterial infections.

Possible Side Effects: 
Nausea, vomiting, diarrhea, rash, bleeding problems, change in kidney or liver function. If patient is allergic, may cause swollen face, throat or lips, breathing difficulties. May also cause a superinfection such as vaginal fungal infection.
Last updated on 02/01/2010

Piperacillin /Tazobactam


Trade Names: 
Zosyn®

Possible Uses: 
Prevent or treat bacterial infections.

Possible Side Effects: 
Nausea, vomiting, diarrhea, rash, bleeding problems, change in kidney or liver function. If patient is allergic, may cause swollen face, throat or lips, breathing difficulties. May also cause a superinfection such as vaginal fungal infection.
Last updated on 02/01/2010

Plerixafor


Trade Names: 
Mozobil®

Possible Uses: 
Use to help mobilize stem cells for collection and subequent autologous transplantation in patients with non-Hodgkin's lymphoma and multiple myeloma

Special Notes: 
This drug is normally given by SQ injection 12 hours prior to collection of stem cells

Drug Interactions: 
no known significant drug interactions

Possible Side Effects: 
fatigue, headache, dizziness, diarrhea, nausea, injection site reactions, and muscle aches, vomiting
Last updated on 02/01/2010

Posaconazole


Trade Names: 
Noxafil®

Possible Uses: 
Use to prevent or treat fungal infections

Special Notes: 
available only as an oral suspension.

Drug Interactions: 
This drug may interfer with many other drugs. Please check with your pharmacist. Avoid grapefuit juice and grapefruits.

Possible Side Effects: 
Diarrhea, headache, dizziness, fatigue,fever, low potassium levels,nausea, constipation, taste perversion,neutropenia, anemia, low platelets count, blurred vision.
Last updated on 02/01/2010

Prednisone


Trade Names: 
Deltasone®
Trade Names: 
Cortan®
Trade Names: 
Orasone®

Possible Uses: 
Decrease swelling, decrease allergic reactions, control nausea or vomiting. May be used as part of chemotherapy regimen. In allogeneic transplants, used to prevent or treat graft rejection.

Possible Side Effects: 
Fluid retention, weight gain, increase in blood sugars, increase in white cell count, restlessness, anxiety, mood changes, sweating, redness in face, thinning skin, acne, increased hair growth, irregular menstrual periods, black bowel movements, muscle weakness or cramps.
Last updated on 02/01/2010

Prochlorperazine


Trade Names: 
Compazine®

Possible Uses: 
Control nausea and vomiting.

Possible Side Effects: 
Drowsiness, dizziness, blurred vision, muscle spasms, jittery feeling, rash, difficulty urinating, dry mouth, nausea, constipation, rapid heartbeat. Rarely, breathing difficulties or seizures.
Last updated on 02/01/2010

Tacrolimus


Trade Names: 
Prograf®

Possible Uses: 
Use orally or IV in allogeneic transplantation to prevent/treat graft vs host disease.

Drug Interactions: 
This drug is dosed to achieve a specific blood level. Many drugs may decrease or increase these levels, please check with your pharmacist.

Possible Side Effects: 
Decreased kidney function, tremor, diarrhea, nause, vomiting, abdominal discomfort, glucose intolerance (high doses)
Last updated on 02/01/2010