|
A Closer Look at the 10
Studies |
|
Studies |
Number of Patients
Randomized |
What the Study
Compared |
Years of
Follow-Up |
Results Thus Far
|
|
Metastatic
Studies |
|
Philadelphia |
199 |
HDC/SCT vs. monthly doses of
CDC (up to 24 months) |
3.1 |
No difference between the two
groups. |
|
Duke |
98 |
HDC/SCT vs. no further therapy
after patients achieved a complete response with CDC |
3.1 |
Transplant patients had lower
relapse rate than those receiving standard-dose chemotherapy. |
|
South African |
154 |
HDC/SCT vs.
CDC |
6 |
Significant survival advantage
for trans-plant patients; study results are currently being audited for
reliability. |
|
French |
61 |
HDC/SCT vs.
CDC |
4.4 |
Patients on transplant arm
survived twice as long as those on CDC arm, but due to small study size, the
difference is statistically significant. |
|
Adjuvant studies for high
risk stage 2-3 |
|
Dutch |
885 |
Four cycles of CDC followed by
HDC/SCT vs. five cycles of CDC |
3.5 |
Significant survival advantage
for the transplant group among the first 200 |
|
American
Inter-group |
783 |
HDC/SCT vs. intermediate-dose
chemotherapy |
3 |
No difference in survival thus
far. More treatment-related deaths in the trans-plant group, but lower relapse
rate as well. Follow-up is short. |
|
Scandinavian |
525 |
HDC/SCT vs. escalating dosages
of chemotherapy with growth factor support |
2 |
No difference in survival or
relapse rate. High incidence of acute myeloid leuke-mia and myelodysplasia in
the group that that did not receive HDC/SCT. |
|
South African |
154 |
HDC/SCT vs.
CDC |
5.3 |
Study results have been
discredited due to misrepresentation of the data by the investigator.
|
|
Dutch |
81 |
HDC/SCT vs. no further therapy
after CDC |
4.1 |
No statistical difference
between the two groups Very small study. |
|
MD Anderson |
78 |
HDC/SCT vs. no further therapy
after CDC |
6.5 |
No statistical difference
between the two groups. Very small study. |
|
Note: HDC/SCT refers to
“high-dose chemotherapy and stem cell transplant”; CDC refers to
“conventional-dose chemo-therapy.” |
